Research
Aevura Research
Advancing Human Longevity Through Unified Biology
At Aevura, we believe that aging is not inevitable — it's programmable. Our research is built around a single unifying idea: that aging is a solvable biological problem. We’re combining insights from molecular biology, data science, and regenerative medicine to push the boundaries of what’s possible in human healthspan.
We’re a UK-based life sciences startup with global ambition — and a singular focus: to identify, understand, and target the core biological mechanisms of aging.
Our Research Areas
1. Systems Biology of Aging
We study aging as an orchestrated breakdown of complex systems, not just the accumulation of damage. By mapping the networks between genes, proteins, and cellular states across the human lifespan, we aim to understand how resilience is lost — and how it can be restored.
- Multi-omics analysis (genomics, proteomics, metabolomics)
- Cross-species comparative aging models
- Longevity-associated gene expression patterns
2. Cellular Senescence & Regeneration
Senescent cells are a hallmark of aging — but not all senescence is the same. Our work focuses on identifying subtypes of senescent cells, understanding their tissue-specific impacts, and exploring strategies to selectively clear or reprogram them.
- In vitro and in vivo senolytic screening
- iPSC-derived tissue regeneration models
- Senescence-associated secretory phenotype (SASP) modulation
3. Mitochondrial Health & Metabolic Reprogramming
Mitochondrial dysfunction is at the heart of age-related decline. We investigate how mitochondrial efficiency, biogenesis, and stress signaling change over time — and how we can reverse metabolic drift.
- Mitochondrial proteomics & bioenergetics
- NAD+ and redox state modulation
- Targeted metabolic therapeutics
4. Epigenetic Clocks & Biomarkers
We’re building next-gen tools to measure biological age — because what gets measured gets improved. From epigenetic methylation clocks to transcriptomic drift, our platform is constantly evolving to improve prediction and personalization.
- DNA methylation-based aging clocks
- Machine learning models of biological age
- Intervention monitoring frameworks
5. Immunosenescence & Inflammation
Chronic, low-grade inflammation — “inflammaging” — is a silent driver of most age-related diseases. We explore how immune system remodeling contributes to tissue degeneration and systemic aging, and how to modulate it.
- Single-cell immune profiling across age
- Anti-inflammatory compound screening
- Immune rejuvenation strategies
Our Scientific Approach
Aevura’s research strategy blends data-driven discovery with therapeutic precision.
We work at the intersection of wet lab biology, in silico modeling, and translational experimentation. Whether it’s using AI to predict protein-ligand interactions or developing personalized senolytic regimens, every project is grounded in real-world impact.
We partner with leading academic institutions, biotech innovators, and translational clinics to move from bench to bedside, faster.
Recent & Upcoming Milestones
- Nature Aging submission on senescent cell subtyping and AI-enhanced SASP modulation
- Launch of the Aevura Biobank for longitudinal biomarker research (Q3 2025)
- Development of our internal Aging Systems Atlas integrating omics and therapeutic data
- Ongoing small molecule screening for mitochondrial-targeted interventions
Our Vision: Translational Longevity
We're not just a research company — we’re building the foundation for real-world therapeutics.
Our long-term goal is to spin out targeted therapeutic programs from our core discoveries — with a focus on regenerative medicine, senolytics, and mitochondrial reprogramming. The future of aging isn’t more years — it’s better ones.
Partner With Us
We welcome collaborations across research, clinical trials, and early-stage biotech development. If you’re aligned with our mission to extend human healthspan through science — let’s talk.